Engineering Escherichia coli for autoinducible production of n-butanol
نویسندگان
چکیده
منابع مشابه
Metabolic engineering of Escherichia coli for 1-butanol production.
Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this...
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BACKGROUND Crude glycerol in the waste stream of the biodiesel production process is an abundant and renewable resource. However, the glycerol-based industry is usually afflicted by the cost for refinement of crude glycerol. This issue can be addressed by developing a microbial process to convert crude glycerol to value-added chemicals. In this study, Escherichia coli was implemented for the pr...
متن کاملSystematic engineering of the central metabolism in Escherichia coli for effective production of n-butanol.
BACKGROUND Microbes have been extensively explored for production of environment-friendly fuels and chemicals. The microbial fermentation pathways leading to these commodities usually involve many redox reactions. This makes the fermentative production of highly reduced products challenging, because there is a limited NADH output from glucose catabolism. Microbial production of n-butanol appare...
متن کاملIn silico prediction of Escherichia coli metabolic engineering capabilities for 1-butanol production
Bashir Sajo Mienda*, Mohd Shahir Shamsir, Faezah Mohd Salleh and Rosli Md. Illias Bioinformatics Research Group (BIRG), Biosciences and Health Sciences Department, Faculty of Biosciences and Medical Engineering, Universiti Teknologi, Malaysia Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia Department of Biologic...
متن کاملMetabolic engineering of Thermoanaerobacterium saccharolyticum for n-butanol production.
The thermophilic anaerobe Thermoanaerobacterium saccharolyticum JW/SL-YS485 was investigated as a host for n-butanol production. A systematic approach was taken to demonstrate functionality of heterologous components of the clostridial n-butanol pathway via gene expression and enzymatic activity assays in this organism. Subsequently, integration of the entire pathway in the wild-type strain res...
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ژورنال
عنوان ژورنال: Electronic Journal of Biotechnology
سال: 2015
ISSN: 0717-3458
DOI: 10.1016/j.ejbt.2015.01.003